Other Emerging Phosphate Binders for Kidney Dialysis Patients

Over the past five years, there are more new generations of phosphate binders for kidney dialysis patients. Some of them are very costly (e.g. Sevelamer and lanthanum carbonate) though effective. There have also been a lot of side-effects associated with these drug intake. For example, nausea and vomiting are pretty common with taking Renagel (sevelamer HCl / carbonate)

Here are some information of the new emerging phosphate binders, in addition to niacin / nicotinamide that this blog has discussed earlier.

However, one has to be cautious in taking these new P-binders. Have to talk to your healthcare providers and monitor your health conditions constantly. For example, taking magnesium-containing binders can render patients more prone to develop hypermagnesium which can lead to defect on electrolyte balance, neuromuscular toxicity etc.

 Latest P-binders:

http://www.healtheconomicsreview.com/content/pdf/2191-1991-1-1.pdf

1. Combination drug of Calcium acetate / Magensium carbonate - Osvaren

http://www.scottishmedicines.org.uk/files/advice/calcium_acetate_and_magnesium_carbonate_Osvaren_FINAL_MARCH_2011_for_website.pdf

http://www.fmc-ag.com/3179.htm

http://ndt.oxfordjournals.org/content/25/11/3707.full.pdf+html

http://www.fmc-renalpharma.com/osvaren.htm

http://www.cvz.nl/binaries/content/documents/cvzinternet/en/documents/assessments/asm1004-calcium-acetate-magnesium-carbonate-osvaren.pdf

http://www.cvz.nl/binaries/content/documents/cvzinternet/en/documents/assessments/asm1004-calcium-acetate-magnesium-carbonate-osvaren.pdf

Note: a cheaper generic version of Phoslo may be available commercially as Calphron from Nephro-Tech. The company also offers Magensbind (magnesium carbonate / calcium carbonate) at both prescription and over-the-counter versions.

http://www.nephrotech.com/order%20information.htm

2. Iron-Magnesium Hydroxycarbonate (Fermagate):

http://cjasn.asnjournals.org/content/4/2/401.full.pdf

  

3. Chitosan-loaded chewing gum

http://jasn.asnjournals.org/content/20/3/639.full.pdf+html

On this, Nestle has acquired CM&D Pharma for making chitosan chewing gums as one of its medical food lead targets.

 http://www.nutraceuticalsworld.com/issues/2011-06/view_editorials/nestle-has-seen-the-light-mdash-have-you-/

http://www.nestlehealthscience.com/SiteCollectionDocuments/Documents/Newsroom%20Documents/2011/FactSheet-Chronic-kidney-disease-hyperphosphataemia-and-its-management.pdf

http://cnfolio.com/media/wsj_nestle_buys_medical_startup.pdf