L-arginine / L-citrulline in Blood Pressure Control

Hi,

In my earlier posting of agents for blood pressure (BP) control, I have referenced some papers on the use of L-arginine / L-citrulline for potential roles in BP reduction. Would like to emphasize that the use of these dietary supplements should be carefully discussed with healthcare providers and monitored. Both compounds act as precursors to facilitate nitric oxide production which may leads to endothelial dilation of blood vessels, thus lowering BP. However, they may also produce the tissue-damaging NO radical that is disadvantageous. Also, they may produce more nitrogenous waste products such as urea in the nitrogen cycle. It is hard to predict which way the two agents will act in our body upon consumption. That may be highly dependent on our physiological condition and health status. So, I would like to point this out here. There is always a risk of taking in agents of unclear mechanisms.